by Elizabeth Tolchin The US Food and Drug Administration (FDA) sat down with a panel of industry leaders today to discuss the pharmaceutical risk-based initiative for current good manufacturing practices (cGMP), announced last year, and its possible impact on industry practices, at the Interphex 2004 PharmaDiscovery Conference in New York City.
by Elizabeth Tolchin Researchers identified a transcriptional mechanism that controls the growth and differentiation of smooth muscles cells. Finding ways to regulate the mechanism could help in the treatment of diseases that result from abnormal growth of smooth muscle cells.
Finding a highly effective siRNA can be a time consuming and labor intensive process, particularly when using publicly available design tools. Ambion (Austin, Texas) and Cenix BioScience (Dresden, Germany) have partnered to eliminate the need to design siRNAs.
Expression Profiling Technology Facilitates Unbiased Differential Expression Analysis And Correlative Gene DiscoveryMarch 15, 2004 4:01 am | Articles | Comments
Gene expression profiling has become a valuable tool and standard protocol in most laboratories. A variety of technologies have evolved for differential gene expression profiling.
by Elizabeth Tolchin Two independent studies identified similar genetic variants for type 2 diabetes susceptibility. The researchers in both studies concentrated their search in the same chromosomal region in two different populations.
by Elizabeth Tolchin A new bioinformatics tool, the Proteomics RIMS (Research Information Management System), announced by Bruker BioSciences Corp. at this week's Pittcon 2004 conference in Chicago, promises the integration of the instrumentation and data analysis associated with proteomics and structure-based research.
Modified Sequencing Grade Aspartic-N. Highly purified Aspartic-N is modified to reduce autolysis, improve stability and simplify protein sequencing procedures.
Grape ( Vitis vinifera ) Array-Ready Oligo Set contains 14,562 70 mer probes representing grape gene transcripts, and is a tool for microarray analysis of grape gene expression. Each probe is melting-temperature normalized and includes a 5' amino linker to facilitate substrate attachment.
FAST® Quant TH1/TH2 antibody arrays provide quantitative detection of nine cytokines in each of 56 samples on standard nitrocellulose coated glass slides, in a familiar microplate footprint.
Agilent Mouse Oligo Microarray Kit G4121A provides the ability to conduct genome-wide profiling research to better understand adverse drug reactions, physiological effects of toxins and toxic substances, and to study genetic diseases such as cancer.
The Applied Biosystems 8500 Affinity Chip Analyzer uses surface plasmon resonance (SPR) technology in a SpotMatrix chip format to facilitate high-throughput affinity analysis and kinetic characterization.
ArrayScan® V TI HCS Reader from Cellomics, Inc., an automated high content screening platform, is a modular, integrated system for large-scale cell biology research using fluorescent cell-based assays.
Corning Incorporated and Promega Corporation have introduced an online tool that allows printing groups and microarray end-users to verify the quality of the cDNA labeling reaction prior to hybridization.
MasterPure Yeast RNA Purification Kit provides the reagents necessary to purify RNA from fungal cell types, including: Candida, Saccharomyces, Schizosaccharomyces, and filamentous fungi, in about 40 minutes.
GeneXP Biosciences, Inc. offers high-throughput gene-expression profiling using automation of Ambion's 96-well MessageAmp process for RNA amplification and labeling. Sample preparation and hybridization processing are performed in 96-well format using standard liquid-handling robotics.