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Protein Crystal Growth Chip

June 4, 2004 5:29 am | Articles | Comments

TOPAZ™ Growth Chip, the first in a new line of chips specialized for generating large, diffraction-quality protein crystals, is important for structural biologists as only half of proteins crystallized by any method turn out to be useful for solving structures.

Army of In Silico Tuberculosis Agents Must Battle to Win Over Experimentalists 6/03/04

June 3, 2004 11:49 am | Articles | Comments

by Catherine Shaffer Treatment for tuberculosis (TB) involves a grueling course of antibiotics that can last a year or more, and there is no effective vaccine. Because the disease manifests differently in humans than in animals, there are also no practical animal models for testing new treatments or vaccines. Now a team of scientists from the University of Michigan, Ann Arbor, Mich., have created a mathematical model of this intractable bacterial...

Chaperone Protein Dissolves Amyloid Plaques 6/02/04

June 2, 2004 8:23 am | Articles | Comments

by Catherine Shaffer Researchers at the Whitehead Institute for Biomedical Research, Cambridge, Mass., have reported in Science Express that yeast chaperone Hsp104 regulates the formation of amyloid fibers by Sup35, a translation termination factor. Sup35 converts to a prion, and the prion form aggregates into beta-sheet-rich amyloid fibers.


Researchers Eye Protein Suspects in Cell Death 06/01/04

June 1, 2004 12:54 pm | Articles | Comments

By Mark Terry Cells have a finite number of divisions, and at each division, chromosome ends, or telomeres, shorten. When the telomeres diminish to a certain length, a number of complex pathways are triggered that halt cell division. In cancer, though, this signaling pathway is disrupted, resulting in unrestrained cell growth.


Cilia May Provide Targets for Obesity and Other Diseases 5/27/04

May 27, 2004 12:01 pm | Articles | Comments

by Catherine Shaffer Two groups of researchers, working independently and using comparative genomic methods, identified a host of genes involved in the formation of cilia and flagella. Defects in these microtubule-based structures, which humans share with all animals and many unicellular organisms such as the algae Chlamydomonas, are blamed for various disorders, such as poor sperm motility, respiratory disorders, kidney disease, and blindness. The...

Drug Resistance Gene May Be Linked to Alzheimer’s Disease Onset 5/26/04

May 26, 2004 11:58 am | Articles | Comments

by Mark Terry Researchers at the Fox Chase Cancer Center, Philadelphia, linked Alzheimer's disease (AD) to a protein that helps cancer cells resist anti-tumor drugs. The protein, ABCA2, is associated with resistance to the cancer drug estramustine. It has also been linked to myelination and nervous system development. Involved in cellular transport, ABCA2 has also been associated with cholesterol loading. A recent report suggests there may be a...


Visualization Tool with Gene Expression Levels Planned for MetaCyc Database 5/25/04

May 25, 2004 11:18 am | Articles | Comments

by Jill Taylor With help from a grant from the National Institute of General Medical Sciences, the MetaCyc database, a metabolic pathway database that allows researchers to visualize metabolic pathways from more than 230 organisms, will soon be expanding both its content and the supporting software tool kit to provide additional querying capabilities, and a richer set of visualizations.

Enzyme Singles Out Misfolded Proteins 5/24/04

May 24, 2004 12:06 pm | Articles | Comments

by Elizabeth Tolchin Researchers identified an enzyme that plays a key role in the recognition of misfolded proteins. The finding, say the researchers, may offer a potential target for several degenerative diseases, including cystic fibrosis, diabetes, and Alzheimer's disease.


Pharma's Apply SNP Discovery To Target Validation 5/21/04

May 21, 2004 1:26 pm | Articles | Comments

by Elizabeth Tolchin In a recent study Hoffmann-La Roche used single nucleotide polymorphism (SNP) discovery and genotyping technologies provided by ParAllele BioScience to identify genetic risk factors for type 2 diabetes.


Inverse Relationship Between pRb2 and VEGF Expression May Diagnose Liver Cancer 5/20/04

May 20, 2004 11:54 am | Articles | Comments

by Mark Terry Researchers identified a relationship between the inverse expression of pRb2/p130 and vascular endothelial growth factor (VEGF) and tumor aggressiveness. Together, they may act as a biomarker for hepatocarcinoma (HCC) or liver cancer.


Square Dish Protects Against Spills

May 20, 2004 5:02 am | Articles | Comments

The Corning® 500 cm 2 Square DW Spillguard Cell Culture Dish is offered for culturing large numbers of anchorage dependent cells. Spillguard multilayer film protects against media spills and contamination during handling and transport to the incubator.

Hollow Fiber, Scale-up System

May 20, 2004 5:02 am | Articles | Comments

FiberCell® Systems Duet™ hollow fiber modules are offered for cell culture scale-up for antibody and recombinant protein production.

Cross-Study Comparisons Identify Reproducible Gene Data 5/19/04

May 19, 2004 12:47 pm | Articles | Comments

by Elizabeth Tolchin With so much genetic expression data being produced by microarrays in the study of cancer, knowing the extent to which these studies agree can provide valuable insight. That is just what researchers from Johns Hopkins University, Baltimore, set out to find.


Rapid Fractionation Of Complex Protein Extracts With Centrifugal MembraneAdsorber Units Improves Detection Of Proteins In 2d Page

May 19, 2004 10:51 am | Articles | Comments

Two-dimensional gel electrophoresis followed by mass spectrometry for protein identification is a reliable and reproducible means of sample analysis. A key element in this process is reducing sample complexity, as samples often consist of tens of thousands of proteins in a magnitude of different concentrations.


FDA Issues Guidance on HIV Drug Combos 5/18/04

May 18, 2004 12:04 pm | Articles | Comments

by Elizabeth Tolchin In a notice issued this week, the US Food and Drug Administration (FDA) announced a new guidance to encourage the development of fixed dose combinations (FDC) and copackaged products for the treatment of HIV infection and AIDS.



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