By Don Monroe Celera Diagnostics (CD), Alameda, Calif., disclosed two more genetic markers that it says are associated with heart-attack risk in caucasians. Although the work is still in an early stage, this type of marker "could be useful in identifying people who should be on statins, or other cholesterol-lowering agents, who otherwise might not be candidates," says Thomas White, chief scientific officer at the company.
By Catherine Shaffer The use of gene therapy in the treatment of brain cancer is hindered by drug delivery problems. Large molecules such as monoclonal antibodies and viral vectors cannot cross the blood-brain barrier. A featured article in the June 1 issue of Clinical Cancer Research now describes the successful delivery of a nonviral RNAi gene therapy to brain tumors in mice, resulting in a significant increase in survival times.
By Mark Terry Researchers with Proteome Sciences Plc., Cobham, UK, recently identified 12 additional phosphorylation sites on the tau protein. Twenty-five phosphorylation sites had previously been identified on tau, which has been implicated in Alzheimer's disease (AD). Neurofibrillary tangles develop from a hyperphosphorylated form of the tau protein, and these are hypothesized to be the cause of neuronal cell death. By using a proprietary mass...
By Don Monroe Vertex Pharmaceuticals Inc., Cambridge, Mass., will get roughly $21 million through 2005 to continue its late-stage drug discovery collaboration with Cystic Fibrosis Foundation Therapeutics Inc. (CFFT), the company announced on May 24.
By Don Monroe First Genetic Trust Inc. (FGT), Deerfield, Ill., and GlaxoSmithKline, Brentford, UK, will again collaborate on a study of possible genetic markers associated with adverse drug reactions, FGT announced on May 25.
By Aaron Sender Researchers at the National Institute of Mental Health's Clinical Brain Disease Branch (NIMH-CBDB) have begun pitting several microarray platforms against each other, trying to find the ones
Promega Rapid Response Reporter Vectors reduce the risk of secondary effects and allow measurement of smaller and more transient changes in transcription compared to their predecessors.
Array-Ready Oligo Set for the Xenopus tropicalis genome contains 10,898 70-mer probes representing Xenopus transcripts.
GeneFishing Technology offers a unique approach for identifying only authentic Differentially Expressed Genes (DEGs) in two or more nucleic acid samples. This technology improves specificity of PCR amplification, enabling researchers to find only real PCR products as a result.
The BTX Electroporation System, ECM 830 was cited in the Journal of Immunology in the paper RNA
Invitrogen Corporation offers custom oligonucleotides manufactured according to Quality System Regulations set forth by the US Food and Drug Administration (FDA).
UltraClean Tissue DNA Kit is offered for the isolation of genomic DNA from animal tissues, cultured cells or rodent tails. Samples are homogenized using timesaving, bead beating technology and DNA is recovered using a silica spin column format in just 20 minutes.
The Ovation Biotin RNA Amplification and Labeling System is offered for use on Affymetrix GeneChip® arrays. IT is validated for reproducibility, fidelity, and sensitivity with GeneChip arrays, using only 5ng of total RNA.
Agilent Mouse Oligo Microarray Kit G4121A provides the ability to conduct genome-wide profiling research to better understand adverse drug reactions, physiological effects of toxins and toxic substances, and to study genetic diseases such as cancer.
Amersham Biosciences has added the CodeLink Human Whole Genome Bioarray to its CodeLink product range. The whole-genome bioarray consolidates genome-wide expression profiling into a single chip microarray experiment and increases assay sensitivity. The single chip presents 54,841 gene targets.