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Veloce System Multiplexes Microfluidic Chromatography 2/5/04

February 6, 2004 5:40 am | Articles | Comments

by Chris Dickey, DrPH Nanostream's analytical system formally announced at LabAutomation 2004

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An Entry Level Liquid Handler 2/4/04

February 6, 2004 4:44 am | Articles | Comments

by Chris Dickey, DrPH Looking to extend its reach into academic and small biotechnology laboratories, Beckman Coulter Inc., Fullerton, Calif., introduced a smaller and less expensive version of its Biomek FX liquid handling system at the LabAutomation 2004 meeting in San Jose, Calif.

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Drews Offers Bleak Outlook for Drug Development 2/3/04

February 3, 2004 12:04 pm | Articles | Comments

by Chris Dickey, DrPH The productivity/innovation gap identified in a now-famous equation developed in 1996 by Juergen Drews, MD, that sent shock waves through the pharmaceutical industry is showing few signs of abating despite the addition of thousands of potential new genomic-based targets.

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Screening Identifies New Class of Anticancer Agents 2/2/04

February 2, 2004 11:52 am | Articles | Comments

by Chris Dickey, DrPH Through use of high-throughput screening, scientists at Hoffmann-La Roche, Nutley, N.J., identified a class of small molecules called Nutlins, which activates the tumor suppressor p53 by preventing the binding of a key inhibitor.

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Pharma Giant Funds Start-Ups 1/30/04

January 30, 2004 1:55 pm | Articles | Comments

by Elizabeth Tolchin Looking for a new source of venture capital for that great idea you've been carrying around? Call Novartis. The Novartis Venture Fund, which recently released its 2003 activity report, committed $35 million in new financing last year.

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Crystallographers and Programs Speak the Same Language 1/29/04

January 29, 2004 2:33 pm | Articles | Comments

by Elizabeth Tolchin There are literally hundreds of small computer programs that analyze diffraction data obtained from x-ray protein crystallography. A new program, called Elves, provides a unified interface that removes the tedious human intervention involved in using those other programs.

Quantitative Measurements Of FRET Using Standard Fluorescence Microscopy

January 29, 2004 10:44 am | Articles | Comments

Fluorescence resonance energy transfer (FRET) is a technique used for quantifying the distance between two molecules conjugated to different fluorophores.

siRNA Transfection Reagent (2569)

January 29, 2004 3:52 am | Articles | Comments

GeneEraser™ siRNA transfection reagent is designed for transfection of siRNA into mammalian cells. This low-toxicity reagent has demonstrated high transfection efficiency of siRNA in a variety of cell lines.

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In Vitro Transcription System

January 29, 2004 3:52 am | Articles | Comments

T7 RiboMAX™ Express RNAi System (a,b,c) is an in vitro transcription system designed for producing milligram amounts of double-stranded RNA (dsRNA) in a short amount of time.

RNA Evaluation Kit

January 29, 2004 3:52 am | Articles | Comments

The RNA Inspector Kit evaluates RNA and cDNA for the presence of transcripts from 1 kb to 14 kb from human, mouse and rat tissues and cell lines. The kit evaluates RNA integrity and quality, the success of cDNA synthesis, and ensures full-length cDNA when constructing cDNA libraries.

siRNA Intracellular Localization

January 29, 2004 3:52 am | Articles | Comments

Label IT® siRNA Tracker Intracellular Localization Kits directly label and deliver siRNA of individual design in an efficient, non-destructive manner, for in vitro tracking experiments.

RNA Transcription Kit

January 29, 2004 3:52 am | Articles | Comments

AmpliScribe™ T7- Flash ™ in vitro transcription kit produces high yields of RNA in a short reaction time. The standard 30 minute kit reaction produces 160 - 180 μg (8 -9 mg/ml) of RNA from 1 μg of DNA template. A 6-fold linear scale up produces >1 mg of RNA in just 30 minutes.

Drosophila RNAi Collection

January 29, 2004 3:52 am | Articles | Comments

The use of RNAi as a genetic tool in Drosophila is made easier through the availability of the Drosophila RNAi Collection, a set of over 7,000 DNA constructs ready for in vitro transcription. The collection consists of dsDNAs covering 50% of the Drosophila genome.

Lamin A/C siRNA/siAb Kit

January 29, 2004 3:52 am | Articles | Comments

The Lamin A/C siRNA/siAb Assay Kit provides a complete, validated assay for silencing a commonly expressed endogenous gene.

RNA From Regions Of Diseased Human Brains

January 29, 2004 3:52 am | Articles | Comments

High quality, DNA free total RNAs are isolated from more than 17 distinct regions of human brains from patients suffering from Alzheimer's, Parkinson's, and AEL. All tissues are ethically obtained and trained neuroanatomists dissect the specific brain regions.

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