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FDA Use of Biomarker Data Finds Likely Support 3/29/04

March 29, 2004 11:09 am | Articles | Comments

by Elizabeth Tolchin In support of the US Food and Drug Administration (FDA) initiative on the use of pharmacogenomic data in the drug submission process, Iconix Pharmaceuticals Inc. is releasing a set of its proprietary Drug Signature genomic biomarkers to the scientific community for research and validation.

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Drug Discovery Software Puts Library on Bench Chemists' Lap 3/26/04

March 26, 2004 11:58 am | Articles | Comments

by Elizabeth Tolchin A structure-guided drug discovery company is using software that allows their bench chemists to handle library design and enumeration. Optive Research Inc., recently deployed the software, called Benchware, for Structural GenomiX (SGX).

Tweaking Microarrays for Comparative Genomics 3/25/04

March 25, 2004 11:47 am | Articles | Comments

by Elizabeth Tolchin Researchers involved in comparative studies of bacterial genomes devised an application of microarray technology in which whole genomes are arrayed on a single glass slide and probed for the presence or absence of specific genes or alleles.

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New Chemical Genomics Facility a Boon to German Researchers 3/24/04

March 24, 2004 7:53 am | Articles | Comments

by Elizabeth Tolchin Researchers at the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Centre (DKFZ), both based in Heidelberg, Germany, have a new Chemical Genomics Facility to call their own. It is one of the first academic facilities for small-molecule screening in Europe.

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Quantitative Gene Expression Analysis Goes Multiplex 3/23/04

March 23, 2004 12:38 pm | Articles | Comments

by Elizabeth Tolchin A new quantitative polymerase chain reaction (qPCR) assay, called BD Qzyme, from BD Biosciences Clontech, allows researchers to more easily quantify multiple target genes in a single sample, according to the company.

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Reaching Into the Population to Understand the Genetics of Infertility 3/22/04

March 22, 2004 12:13 pm | Articles | Comments

by Elizabeth Tolchin As part of a massive genetics-based infertility study, researchers from the Whitehead Institute will examine the prevalence for deletions in a specific region of the Y-chromosome from over 20,000 male DNA samples provided by Genomics Collaborative Inc. (GCI).

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Pharmacogenomics Gives Pfizer a Better Picture of Its Pipeline 3/19/04

March 19, 2004 11:46 am | Articles | Comments

by Elizabeth Tolchin Pfizer Inc. shared its approach to pharmacogenomics and how it is applied to their drug discovery pipeline, this week at PharmaDiscovery2004, held in New York's Jacob Javits Convention Center.

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DNA Sequencing Gets a Kick from Geospiza's Finch 3/18/04

March 18, 2004 12:59 pm | Articles | Comments

by Elizabeth Tolchin A not so new tool for DNA sequence workflow automation is getting interest from pharmaceutical companies large and small. Geospiza Inc. announced two successful rollouts of the Finch Sequencing Center this week.

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Assessing Drugs Through In Vitro/In Situ ADME Screening 3/17/04

March 18, 2004 6:09 am | Articles | Comments

by Elizabeth Tolchin Best practices for using ADME data and in vitro/in situ models was the focus of one talk today given by an Aventis scientist at the Interphex 2004 Conference and Exposition, held in New York's Jacob Javits Convention Center.

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FDA Discusses Risk Management Initiative with Industry 3/16/04

March 16, 2004 12:16 pm | Articles | Comments

by Elizabeth Tolchin The US Food and Drug Administration (FDA) sat down with a panel of industry leaders today to discuss the pharmaceutical risk-based initiative for current good manufacturing practices (cGMP), announced last year, and its possible impact on industry practices, at the Interphex 2004 PharmaDiscovery Conference in New York City.

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Protein Essential for Smooth Muscle Regulation 3/15/04

March 15, 2004 11:35 am | Articles | Comments

by Elizabeth Tolchin Researchers identified a transcriptional mechanism that controls the growth and differentiation of smooth muscles cells. Finding ways to regulate the mechanism could help in the treatment of diseases that result from abnormal growth of smooth muscle cells.

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siRNAs to Human, Mouse, and Rat Genomes

March 15, 2004 6:08 am | Articles | Comments

Finding a highly effective siRNA can be a time consuming and labor intensive process, particularly when using publicly available design tools. Ambion (Austin, Texas) and Cenix BioScience (Dresden, Germany) have partnered to eliminate the need to design siRNAs.

Expression Profiling Technology Facilitates Unbiased Differential Expression Analysis And Correlative Gene Discovery

March 15, 2004 4:01 am | Articles | Comments

Gene expression profiling has become a valuable tool and standard protocol in most laboratories. A variety of technologies have evolved for differential gene expression profiling.

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Studies Find Similar Genetic Variants for Type 2 Diabetes 3/12/04

March 12, 2004 12:16 pm | Articles | Comments

by Elizabeth Tolchin Two independent studies identified similar genetic variants for type 2 diabetes susceptibility. The researchers in both studies concentrated their search in the same chromosomal region in two different populations.

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Expression, Interaction and Structure Unite in Proteomics Research System 3/11/04

March 11, 2004 12:16 pm | Articles | Comments

by Elizabeth Tolchin A new bioinformatics tool, the Proteomics RIMS (Research Information Management System), announced by Bruker BioSciences Corp. at this week's Pittcon 2004 conference in Chicago, promises the integration of the instrumentation and data analysis associated with proteomics and structure-based research.

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