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In-Gel Digestion And Purification Prior To Mass Spectrometry

May 5, 2004 4:30 am | Articles | Comments

Use of 1- or 2-D gel electrophoresis followed by enzymatic digestion and mass spectrometry (MS) analysis is currently the most predominant workflow for protein identification.

Phenotype Array Speeds Research on Bioremediation Bugs 5/3/04

May 3, 2004 1:12 pm | Articles | Comments

by Elizabeth Tolchin As part of the Genomics:GTL (formerly Genomes to Life) project, funded by the US Department of Energy, researchers from Lawrence Berkeley National Laboratory, Berkeley, Calif., are using phenotype microarrays to rapidly deduce the stress-response pathways in metal- and radionuclide-reducing bacteria.


Bio-Barcode Diagnostic Method Could Rival PCR 4/30/04

April 30, 2004 1:21 pm | Articles | Comments

by Elizabeth Tolchin A group of chemists at Northwestern University, Chicago, claim they developed a diagnostic method that is much faster, easier to use, more accurate, and less expensive than polymerase chain reaction (PCR).


Cell-Based Assay Development for HTS

April 30, 2004 4:33 am | Articles | Comments

Eleventh Annual Cell-Based Assay Development for HTS May 17-18, 2004, Philadelphia, Pennsylvania

Cartesian Robots

April 29, 2004 9:21 am | Articles | Comments

Parker XRS Systems, pre-engineered cartesian robots, offer off the shelf multi-axis solutions for liquid handling, microarrays and liquid dispensing. Over 120 standard XY and XYZ systems are available with payloads up to 25 kg and work areas to 1 × 1 meter.


FDA Takes Control of Pancreatic Enzyme Products 4/29/04

April 29, 2004 8:13 am | Articles | Comments

by Elizabeth Tolchin In a final resolution to a long-labored issue, the US Food and Drug Administration (FDA) issued a mandate this week requiring all pancreatic extract manufacturers to have their products approved by the FDA within the next four years in order to remain on the market.


CROs and Pharmas Discuss the Reality of Strategic Relationships 4/28/04

April 28, 2004 9:06 am | Articles | Comments

by Elizabeth Tolchin According to participants and conference organizers, much of the buzz at the 13th Annual Partnerships with CROs & Other Outsourcing Providers conference, taking place this week in Orlando, Fla., was on a new strategic partnership model. But some say it's an idea that is not materializing.


New Functional Assays For Multidrug Resistance

April 28, 2004 6:26 am | Articles | Comments

Intrinsic and acquired drug resistance to various classes of chemically diverse chemotherapy agents (referred to as "MultiDrug Resistance", MDR) represents the major obstacle in modern cancer chemotherapy.


New Protein Assay Tests for Multidrug Resistance 4/26/04

April 26, 2004 11:59 am | Articles | Comments

by Robert Ford An assay technology developed by a Hungarian company should enable researchers at MDS Pharma Services, Montreal, Canada, to better ensure that patients using multiple medications are receiving the full dosage of their medication rather than excreting them.


ASU Sees Sunny Future For Tech Transfer 4/23/04

April 23, 2004 12:27 pm | Articles | Comments

by Elizabeth Tolchin With antiquated legislation going back to the Wild West days, Arizona is one of the only remaining states to not allow its universities to take equity positions in companies stemming from scientific discoveries by faculty. That may change in November when a new bill concerning technology transfer will be posted with the state general election.


Manufacturing a More Powerful T Cell Against Cancer 4/22/04

April 23, 2004 8:24 am | Articles | Comments

by Elizabeth Tolchin As part of a phase I Small Business Innovation Research (SBIR) grant from the National Cancer Institute, Bethesda, Md., Aastrom Biosciences Inc. will conduct a $124,000, eight-month study to demonstrate the feasibility and advantages of their technology to culture T lymphocytes or T cells for treatment against malignant melanoma.


Oligos Block Small RNA Function and Call Out Proteins 4/21/04

April 22, 2004 8:11 am | Articles | Comments

by Elizabeth Tolchin Inserting a 2´-O-methyl oligonucleotide into a cell can inhibit small RNA function. That was the method demonstrated by researchers from the University of Massachusetts Medical School, Worcester.


Mapping Brain Genes in 3D 4/20/04

April 20, 2004 1:02 pm | Articles | Comments

by Elizabeth Tolchin Researchers at the University of Illinois, Chicago, are developing an interactive gene expression map of the brain, as part of The Human Brain Project (HBP).


Fishing for Antigens in Insects 4/16/04

April 16, 2004 12:39 pm | Articles | Comments

by Elizabeth Tolchin A baculovirus-based method permits insect cells infected with a virus encoding a library of peptides to display unique major histocompatibility complexes (MHCs) on their surface.


Quantitative Mouse Models Allow Increase or Decrease in Gene Expression 4/15/04

April 15, 2004 11:37 am | Articles | Comments

by Elizabeth Tolchin A pioneer in developing procedures for creating mouse models for gene targeting has now developed a technique for altering the level of expression of a chosen gene in mice without changing its function.


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