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Compound Handling Facility Increases Capabilities

November 17, 2003 10:58 am | Articles | Comments

Specs has opened a new processing facility in Cumberland, MD. The 12,000 square foot site houses six weighing stations, barcode printers, robotics liquid handling and plating equipment and space for long-term compound storage.

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Capillary Coatings Optimize Separations

November 17, 2003 10:58 am | Articles | Comments

The EOTrol™ suite of dynamic coating reagents for electrophoretic separations enables life scientists and analytical chemists to optimize resolution and throughput, and to improve reproducibility in capillary and microchannel electrophoretic separations.

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Hot Plates, Stirring Hot Plates

November 17, 2003 10:58 am | Articles | Comments

Barnstead/Thermolyne brand Cimarec® hot plates and stirring hot plates incorporate digital technology and enhanced safety features. High wattage allows liquids to be quickly brought to a boil. Digital control ensures repeatable, accurate temperatures.

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Chemiluminescent Substrate

November 17, 2003 10:58 am | Articles | Comments

BioFX chemiluminescent substrates provide sensitive detection in immunoassay and immunoblotting applications. The reagents are intensified and their signal duration increased using proprietary enhancers.

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Plasmid Purification System

November 17, 2003 10:58 am | Articles | Comments

SprintPrep™ plasmid purification system, based on Agencourt's patented SPRI™ chemistry, enables plasmid purification in less than 15 minutes. Carboxylate-modified paramagnetic microparticles separate cellular debris and genomic DNA from plasmid DNA without centrifugation or filtration steps.

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Giant Liposomes Make Tiny Test Tubes

November 17, 2003 8:56 am | Articles | Comments

by Elizabeth Tolchin Scientists have found a new technique for performing ultra-small-volume chemical reactions. The technique uses giant (cell-sized) liposomes as nanovials and an ultraviolet laser pulse to fuse them together. The approach may be useful for faster, cheaper identification of new pharmaceuticals and for studying cellular-level processes.

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Bacteria Cranks Up Mutation Apparatus When Starved 11/14/03

November 14, 2003 11:44 am | Articles | Comments

by Pam Holland-Moritz Starving Escherichia coli bacteria appears to increase their ability to mutate and adapt to the situation. Spontaneous mutations are quite normal in bacteria under environmental stress, but a report published in Molecular Microbiology [J. C. Layton, P. L. Foster, vol. 50, pp. 549-561 (2003)] showed that some bacteria increase genetic mutations in response to nutrient restriction.

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Confocal Microscope Systems - A Comparison Of Technologies

November 14, 2003 4:34 am | Articles | Comments

Confocal microscopy offers a number of advantages when compared with traditional widefield optical microscopy. Confocal systems occlude out-of-focus light, vastly improving imaging contrast.

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Protein Disulfide-Isomerase Accelerates Protein Refolding

November 13, 2003 10:18 am | Articles | Comments

Protein disulfide-isomerase (PDI) is an enzyme that in mammalian cells catalyzes post-translational thiol-disulfide exchange reactions in expressed proteins. Such exchanges lead to refolding of the protein and greatest overall protein stability. Protein folding can particularly be a problem for E.

Human HO-1 ELISA Kit

November 13, 2003 10:18 am | Articles | Comments

The StressXpress™ Human HO-1 ELISA Kit provides a reproducible method for quantifying human Heme Oxygenase-1 in a variety of sample types. The kit detects as little as 0.78 ng/ml, and has a range of 0.78-25 ng/ml. Once samples are prepared, the assay takes less than 3 hours to perform.

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Recombinant Human Furin

November 13, 2003 10:18 am | Articles | Comments

Recombinant Human Furin is offered by R&D Systems. Furin is a member of the proprotein convertase (PC) family that belongs to the subtilisin superfamily of serine proteases.

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Apoptosis Detection Kits

November 13, 2003 10:18 am | Articles | Comments

Magic Red™ substrate-based assays detect protease activity within whole living cells, and are based on a cresyl violet leaving group that fluoresces once enzyme specific peptides are cleaved.

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Apoptosis Assays (2095)

November 13, 2003 10:18 am | Articles | Comments

Apoptosis Suite enables examination of three separate biological aspects of cell death in order to assess whether each cell is in the early- mid- or late-stages of apoptosis. The suite includes assays for membrane changes (Annexin V), activation of caspase enzymes, and DNA fragmentation (TUNEL).

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Localization Vectors (2093)

November 13, 2003 10:18 am | Articles | Comments

New BD Living Colors™ subcellular localization vectors pHcRed1-Nuc and pHcRed1-Mito express the far-red fluorescent protein HcRed1 fused to a localization tag. Far-red shifted fluorescence easily distinguishes HcRed1 from other fluorescent proteins.

Glutamate NMDA Receptor (Neuroscience) Antibody

November 13, 2003 10:18 am | Articles | Comments

Monoclonal antibody offered to glutamate NMDA Receptor subunits 3A and 3B recognizes both NR3A and NR3B subunits in Western Blot and immunohistochemistry applications. NR3B is the final member of the NMDA subtype of the glutamate receptor (NMDAR) family to be cloned and characterized.

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