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Pharmacogenomics Gives Pfizer a Better Picture of Its Pipeline 3/19/04

March 19, 2004 11:46 am | Articles | Comments

by Elizabeth Tolchin Pfizer Inc. shared its approach to pharmacogenomics and how it is applied to their drug discovery pipeline, this week at PharmaDiscovery2004, held in New York's Jacob Javits Convention Center.

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DNA Sequencing Gets a Kick from Geospiza's Finch 3/18/04

March 18, 2004 12:59 pm | Articles | Comments

by Elizabeth Tolchin A not so new tool for DNA sequence workflow automation is getting interest from pharmaceutical companies large and small. Geospiza Inc. announced two successful rollouts of the Finch Sequencing Center this week.

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Assessing Drugs Through In Vitro/In Situ ADME Screening 3/17/04

March 18, 2004 6:09 am | Articles | Comments

by Elizabeth Tolchin Best practices for using ADME data and in vitro/in situ models was the focus of one talk today given by an Aventis scientist at the Interphex 2004 Conference and Exposition, held in New York's Jacob Javits Convention Center.

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FDA Discusses Risk Management Initiative with Industry 3/16/04

March 16, 2004 12:16 pm | Articles | Comments

by Elizabeth Tolchin The US Food and Drug Administration (FDA) sat down with a panel of industry leaders today to discuss the pharmaceutical risk-based initiative for current good manufacturing practices (cGMP), announced last year, and its possible impact on industry practices, at the Interphex 2004 PharmaDiscovery Conference in New York City.

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Protein Essential for Smooth Muscle Regulation 3/15/04

March 15, 2004 11:35 am | Articles | Comments

by Elizabeth Tolchin Researchers identified a transcriptional mechanism that controls the growth and differentiation of smooth muscles cells. Finding ways to regulate the mechanism could help in the treatment of diseases that result from abnormal growth of smooth muscle cells.

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siRNAs to Human, Mouse, and Rat Genomes

March 15, 2004 6:08 am | Articles | Comments

Finding a highly effective siRNA can be a time consuming and labor intensive process, particularly when using publicly available design tools. Ambion (Austin, Texas) and Cenix BioScience (Dresden, Germany) have partnered to eliminate the need to design siRNAs.

Expression Profiling Technology Facilitates Unbiased Differential Expression Analysis And Correlative Gene Discovery

March 15, 2004 4:01 am | Articles | Comments

Gene expression profiling has become a valuable tool and standard protocol in most laboratories. A variety of technologies have evolved for differential gene expression profiling.

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Studies Find Similar Genetic Variants for Type 2 Diabetes 3/12/04

March 12, 2004 12:16 pm | Articles | Comments

by Elizabeth Tolchin Two independent studies identified similar genetic variants for type 2 diabetes susceptibility. The researchers in both studies concentrated their search in the same chromosomal region in two different populations.

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Expression, Interaction and Structure Unite in Proteomics Research System 3/11/04

March 11, 2004 12:16 pm | Articles | Comments

by Elizabeth Tolchin A new bioinformatics tool, the Proteomics RIMS (Research Information Management System), announced by Bruker BioSciences Corp. at this week's Pittcon 2004 conference in Chicago, promises the integration of the instrumentation and data analysis associated with proteomics and structure-based research.

Modified Sequencing Grade Aspartic-N

March 11, 2004 8:45 am | Articles | Comments

Modified Sequencing Grade Aspartic-N. Highly purified Aspartic-N is modified to reduce autolysis, improve stability and simplify protein sequencing procedures.

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Grape Genome Oligo Set

March 11, 2004 5:20 am | Articles | Comments

Grape ( Vitis vinifera ) Array-Ready Oligo Set contains 14,562 70 mer probes representing grape gene transcripts, and is a tool for microarray analysis of grape gene expression. Each probe is melting-temperature normalized and includes a 5' amino linker to facilitate substrate attachment.

Antibody Microarrays

March 11, 2004 5:20 am | Articles | Comments

FAST® Quant TH1/TH2 antibody arrays provide quantitative detection of nine cytokines in each of 56 samples on standard nitrocellulose coated glass slides, in a familiar microplate footprint.

Mouse Oligo Microarray

March 11, 2004 5:20 am | Articles | Comments

Agilent Mouse Oligo Microarray Kit G4121A provides the ability to conduct genome-wide profiling research to better understand adverse drug reactions, physiological effects of toxins and toxic substances, and to study genetic diseases such as cancer.

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Binding Interaction Measurement

March 11, 2004 5:20 am | Articles | Comments

The Applied Biosystems 8500 Affinity Chip Analyzer uses surface plasmon resonance (SPR) technology in a SpotMatrix chip format to facilitate high-throughput affinity analysis and kinetic characterization.

High Content Screening Reader

March 11, 2004 5:20 am | Articles | Comments

ArrayScan® V TI HCS Reader from Cellomics, Inc., an automated high content screening platform, is a modular, integrated system for large-scale cell biology research using fluorescent cell-based assays.

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