Genes for Multiple Sclerosis Found Using 100K SNP Arrays
Researchers say benefits easily outweigh costs
System outperforms cluster-based approaches
Doing more with less coverage
Life scientists haven't had time to rest on their laurels since the completion of the human genome project. According to Jeff Peterson, CEO of Target Discovery (Palo Alto, CA), the incomplete correlation between protein and gene expression led to the first major realization of the post-genomic era.
DNA cloning is the basis for many biological investigations. Whether the goal is to sequence an entire genome, learn all there is to know about one protein, or decipher the regulation of a particular pathway, the integrity of early DNA amplification and cloning experiments can determine the success of a research project.
MicroRNAs (miRNAs) are small, siRNA-like molecules encoded in the genomes of plants and animals. They regulate gene expression by binding to and modulating the translation of specific mRNAs.
GeneChip Mapping 10K 2.0 Array and GeneChip Mapping 100K Array Set facilitate genotyping over 10,000 SNPs and provide an array set for genotyping over 100,000 SNPs.
Plate Arraying on the BioRobotics MicroGrid II and the GeneMachines OmniGrid Accent, both from Genomic Solutions, enables the production of DNA and protein microarrays in 96- and 384-well microplates and allows the printing of over 1000 features within an individual well in a 96-well microplate.
The DASL assay (Illumina, Inc.) generates reproducible gene expression profiles from formalin-fixed paraffin-embedded (FFPE) samples and other samples containing partially degraded RNAs. The assay enables the measurement of RNA abundance of over 500 genes in parallel per sample.
PIQOR SkinPatho microarray is comprised of 1,132 genes associated with pathological expression changes in human skin. It is available as part of the Miltenyi Biotec Microarray Service.
Micro Spotting Devices, 946, Stealth and ChipMaker are used in microarray manufacturing. A full line of stock and custom print heads are available to fit any robot. Spot sizes range from 50-600 mm, depending on the tip size.
ArrayPure nano-scale RNA purification kit provides all reagents needed to purify RNA from one to ten thousand eukaryotic cells, as obtained with laser capture methods. The kit contains only aqueous solutions and requires no toxic organic solvents.
Human Genome CGH Microarray and CGH Analytics software (Agilent Technologies, Inc.) aids cancer biologists and cytogeneticists in the study of genomic alterations in cancer.
Eppendorf DualChip microarray systems are offered for gene expression analysis and pathway identifications in toxicology, neuroscience, signal transduction and research on aging using human or rat models.