RNAi targets gene silencing, and is achieved in mammalian cells through the use of short interfering RNA molecules, or siRNAs. RNAi has accelerated the functional characterization of disease-relevant genes for drug discovery and basic research efforts.
Global 2019 rodent diet is designed to improve reproduction and performance of genetically engineered mice and other poorly performing rodents. It contains 19% protein and 9% fat content, and meets the nutrient requirements of gestation, lactation, and early growth of rats and mice.
Custom monoclonal and polyclonal antibody development through genetic immunization involves direct immunization of the host animal with plasmid DNA encoding a protein of interest. The immunized host then produces the encoded protein and raises antibodies.
Colorimetric and fluorescent assays and biosensors detect viruses, bacteria, parasites, and other pathogens. They consist of biologically or chemically specific receptor ligands attached to a polydiacetylene backbone.
FIA-SIA-LOV Sequential Injection Analyzer combines a computer-controlled six-position valve, precision syringe pump, and spectrophotometric flow cell that automates wet-chemistry lab procedures.
Microwave fixation quickly and effectively halts brain chemical activity. Several important brain chemicals, including acetylcholine, dopamine, DARPP-32, HVA, and c-AMP begin changing rapidly at death.
The Library of Pharmacologically-Active Compounds (LOPAC 1280 ) is a collection of 1,280 characterized small ligands used for assay validation and orphan receptor characterization.
Resin-bound oxidizing reagent, MP-TsO-TEMPO, for alcohol oxidation, assists medicinal chemists in increasing the diversity of targeted drug compounds.
The AutoGenprep 965, a completely automated 96 well format robotic system for DNA extraction, produces high yields of quality DNA at a very low cost per prep. The 965 was recently released with a protocols for whole blood and BAC/plasmid.
Biodesign International has recently added myostatin antibodies to its line of over 300 cytokine and growth factor products. Myostatin is a member of the transforming growth factor-beta (TGF-beta) family of secreted regulatory factors.
Orbit Digital Shakers are offered in six versions to accommodate a range of microplates, micro tubes, flat containers, dishes and culture flasks. The 3 mm models provide vigorous mixing of small volume samples like 96 well plates and micro tubes.
Barnstead/Thermolyne brand Cimarec® hot plates and stirring hot plates offer digital technology and enhanced safety features. High wattage boils liquids quickly. Digital microprocessor-controlled technology ensures repeatable, accurate temperatures.
VWR and VWR Signature heated and refrigerated circulators featuring enhanced electronics that allow intuitive, user-friendly programming and control.
Ambion, Inc. (Austin, Tex. and Cenix BioScience GmbH (Dresden, Germany) have announced that siRNA designs have been completed for more than 98% of all human, mouse, and rat genes listed in the public RefSeq database.