11/24/03 A new method identifies RNA-binding proteins involved in a variety of human diseases.
11/25/03Researchers fashioned a superior binding ligand from altered green fluorescent proteins (GFPs) that combines the high affinity and specificity of antibodies with the fluorescence that is ideal for detection.
by Elizabeth Tolchin Using the recently available Drosophila melanogaster genome sequence, a group of researchers predicted a total of 14,202 transcripts and built a genome-scale protein interaction map.
The Elx405 HT washer for 384-well microplates features the processing speed, carrier design and footprint to facilitate integration into automated systems requiring high-throughput washing.
The CCDBIO® SmartIMAGE PERSONAL and the CCDBIO SmartIMAGE SYSTEM combine advanced CCD technologies, darkroom components and software. CCDBIO SmartIMAGE PERSONAL is a gel documentation product for individual use.
Bench-top 2D gel electrophoresis system a2DE is fully automated, removing the labor-intensive phases of manual 2D electrophoresis.
Specs has opened a new processing facility in Cumberland, MD. The 12,000 square foot site houses six weighing stations, barcode printers, robotics liquid handling and plating equipment and space for long-term compound storage.
The EOTrol suite of dynamic coating reagents for electrophoretic separations enables life scientists and analytical chemists to optimize resolution and throughput, and to improve reproducibility in capillary and microchannel electrophoretic separations.
Barnstead/Thermolyne brand Cimarec® hot plates and stirring hot plates incorporate digital technology and enhanced safety features. High wattage allows liquids to be quickly brought to a boil. Digital control ensures repeatable, accurate temperatures.
BioFX chemiluminescent substrates provide sensitive detection in immunoassay and immunoblotting applications. The reagents are intensified and their signal duration increased using proprietary enhancers.
SprintPrep plasmid purification system, based on Agencourt's patented SPRI chemistry, enables plasmid purification in less than 15 minutes. Carboxylate-modified paramagnetic microparticles separate cellular debris and genomic DNA from plasmid DNA without centrifugation or filtration steps.
by Elizabeth Tolchin Scientists have found a new technique for performing ultra-small-volume chemical reactions. The technique uses giant (cell-sized) liposomes as nanovials and an ultraviolet laser pulse to fuse them together. The approach may be useful for faster, cheaper identification of new pharmaceuticals and for studying cellular-level processes.
by Pam Holland-Moritz Starving Escherichia coli bacteria appears to increase their ability to mutate and adapt to the situation. Spontaneous mutations are quite normal in bacteria under environmental stress, but a report published in Molecular Microbiology [J. C. Layton, P. L. Foster, vol. 50, pp. 549-561 (2003)] showed that some bacteria increase genetic mutations in response to nutrient restriction.
Confocal microscopy offers a number of advantages when compared with traditional widefield optical microscopy. Confocal systems occlude out-of-focus light, vastly improving imaging contrast.
Protein disulfide-isomerase (PDI) is an enzyme that in mammalian cells catalyzes post-translational thiol-disulfide exchange reactions in expressed proteins. Such exchanges lead to refolding of the protein and greatest overall protein stability. Protein folding can particularly be a problem for E.