Biomarkers to Be Included in Tests for Prostate and Breast Cancer
A new class of drugs called PARP inhibitors
Vascular targeted prodrug with controlled activity
Searching by organism for potential targets
Analyzing the genes associated with aging
Inhaled Synthetic from Marijuana Advances
Method for creating more diverse tetracyclines
Promising comprehensive coverage
Protein knockout produces fat-burning mice
G protein coupled receptors (GPCRs) are a major class of targets for drug discovery and frequently are targets within high throughput screening (HTS) laboratories. (1) Although GPCRs are a large, diverse and highly conserved class of membrane-bound proteins, signaling principally involves modulation of only two membrane-bound enzymes, adenylyl cyclase and phospholipase C.
The microflex LT benchtop MALDI-TOF mass spectrometer (Bruker Daltonics) is offered for clinical proteomics and for the routine analysis of peptides, proteins and other large molecules. Due to a gridless ion source, this instrument provides sensitivity in both positive and negative ion mode.
ProteomeScan generates images of up to 12,800 × 12,800-dpi max output resolution, ensuring that small protein spots are detected.
Macroporous reversed-phase C18 (mRP-C18) high-recovery protein fractionation and desalting LC column (Agilent Technologies) enables detection and identification of potential biomarkers in complex samples, such as serum or plasma, by providing sample recovery of greater than 95%.
SPN and SPN-htp protein assays, suitable for use with as little as 0.5 μg protein, resist interference from common laboratory agents.
pIRES2-ZsGreen1 or pZsGreen1-1 fluorescent protein vectors are offered for cellular assays. pIRES2-ZsGreen1 contains an internal ribosome entry site (IRES), which permits both the cloned gene and the ZsGreen1-encoding region to be translated from a single mRNA.