Parkinson's Disease (PD) is a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra pars compacta. The gene encoding human parkin has been linked to an autosomal recessive form of PD.
Charles River Proteomic Services Inc. (Worcester, MA) and GenWay Biotech Inc. (San Diego, CA) have collaborated to produce avian IgY polyclonal antibodies that function as a fractionation step prior to protein separation.
In vitro-derived, recombinant antibody is targeted against human Cyclophilin A, which is indicated to play an important role in the mechanism of protein folding. Recently a number of diseases have been linked to protein folding problems.
HTRF-based cGMP (Cyclic GMP) Assay kit (Cisbio International), a homogenous cGMP assay, is based
Assay Designs has introduced an immunoassay for the quantitative determination of human Smac/DIABLO in cell lysates. The colorimetric, 96 well-plate format measures Smac/DIABLO concentration with a range of 31.25 to 1000 pg/ml. The three-hour assay is non-radioactive, stable, and sensitive to 7.
The Automatic Perfused HFB (Hydrodynamic Focusing Bioreactor) System is a multi-purpose bioreactor that provides automatic control of major process parameters. The system is equipped with controls for pH, D.O.
Delivery technology from Nektar Therapeutics
Living cells have emerged as indispensable tools in pharmaceutical screening and in fundamental research. Their application encompasses the evaluation of drug candidates in high-throughput screening (HTS) and ADME-tox assays for the assessment of metabolic behavior and toxicity of new compounds as well as questions emanating from basic research.
Nylon wool fiber (NWF), used for separating T-cell and B-cell lymphocytes, is available in quantities of 10g and 50g, enabling users to pack columns of any size. Wool fiber uses include removing B-cells from blood and isolating T-cells with excellent viability for routine phenotyping.
VEC Technologies, Inc. manufacturers normal cultured vascular endothelial cells and endothelial cell support products. Endothelial cells are available from various species and several different anatomic sites. Custom isolation services are also provided.
D-Tube Dialyzers dialyze sample volumes from 10 to 3000 μl. Screw-cap tubes with an integrated regenerated cellulose membrane, they are easy to load and unload. They can also be used to electroelute DNA, RNA, protein or protein-DNA complexes from agarose and PAGE gels.
Stronghold clamps, connectors and lattices are constructed of nylon with 30% glass fiber. The materials produce increased strength, reduced weight and chemical resistance properties. Surfaces are non-corroding and resistant to salts and most solvents.
The yeast shuttle vector pORF-CLONE is an intelligent method for an easy and cost-effective selection of clones containing long cDNA inserts with a correct open reading frame (ORF).
PictureFrame 2.2 camera control and image-processing software package is offered for a proprietary line of scientific grade CCD cameras for microscopy. A new graphical user interface (GUI) is included, which controls the CRI Macro-Color tunable liquid crystal RGB filter.
The Gemini C18 HPLC column achieves extended pH 1-12 stability with silica performance by using a silica manufacturing process. The extreme pH ruggedness permits method developers to perform cyclic pH testing for rapid method development.