TOPAZ Growth Chip, the first in a new line of chips specialized for generating large, diffraction-quality protein crystals, is important for structural biologists as only half of proteins crystallized by any method turn out to be useful for solving structures.
MessageAmp II aRNA Amplification Kit incorporates ArrayScript M-MLV RT to maximize yields of full length cDNA. MessageAmp II selects and amplifies mRNA from as little as 100 ng of input RNA in a single round of amplification for GeneChip® analysis.
The Trilogy platform (U.S. Genomics) provides direct detection and quantitation of individual molecules of DNA, RNA and proteins without the need for amplification.
High speed, room temperature DNA storage and retrieval platform, the GenVault Personal Archive storage system, facilitates on-site management of multiple DNA samples.
The Drummond Pipet-Aid Elite facilitates fast, accurate, pipetting and allows easy, comfortable operation. The lightweight Elite features intuitive user-friendly programming functions and "Easy Touch" buttons.
by Catherine Shaffer Treatment for tuberculosis (TB) involves a grueling course of antibiotics that can last a year or more, and there is no effective vaccine. Because the disease manifests differently in humans than in animals, there are also no practical animal models for testing new treatments or vaccines. Now a team of scientists from the University of Michigan, Ann Arbor, Mich., have created a mathematical model of this intractable bacterial illness, and are campaigning for its acceptance among experimentalists.
by Catherine Shaffer Researchers at the Whitehead Institute for Biomedical Research, Cambridge, Mass., have reported in Science Express that yeast chaperone Hsp104 regulates the formation of amyloid fibers by Sup35, a translation termination factor. Sup35 converts to a prion, and the prion form aggregates into beta-sheet-rich amyloid fibers.
By Mark Terry Cells have a finite number of divisions, and at each division, chromosome ends, or telomeres, shorten. When the telomeres diminish to a certain length, a number of complex pathways are triggered that halt cell division. In cancer, though, this signaling pathway is disrupted, resulting in unrestrained cell growth.
by Catherine Shaffer Two groups of researchers, working independently and using comparative genomic methods, identified a host of genes involved in the formation of cilia and flagella. Defects in these microtubule-based structures, which humans share with all animals and many unicellular organisms such as the algae Chlamydomonas, are blamed for various disorders, such as poor sperm motility, respiratory disorders, kidney disease, and blindness. The genes identified may offer novel drug targets for these disorders.
by Mark Terry Researchers at the Fox Chase Cancer Center, Philadelphia, linked Alzheimer's disease (AD) to a protein that helps cancer cells resist anti-tumor drugs. The protein, ABCA2, is associated with resistance to the cancer drug estramustine. It has also been linked to myelination and nervous system development. Involved in cellular transport, ABCA2 has also been associated with cholesterol loading. A recent report suggests there may be a connection between the transport molecule and the mechanisms behind AD.
by Jill Taylor With help from a grant from the National Institute of General Medical Sciences, the MetaCyc database, a metabolic pathway database that allows researchers to visualize metabolic pathways from more than 230 organisms, will soon be expanding both its content and the supporting software tool kit to provide additional querying capabilities, and a richer set of visualizations.
by Elizabeth Tolchin Researchers identified an enzyme that plays a key role in the recognition of misfolded proteins. The finding, say the researchers, may offer a potential target for several degenerative diseases, including cystic fibrosis, diabetes, and Alzheimer's disease.
by Elizabeth Tolchin In a recent study Hoffmann-La Roche used single nucleotide polymorphism (SNP) discovery and genotyping technologies provided by ParAllele BioScience to identify genetic risk factors for type 2 diabetes.
by Mark Terry Researchers identified a relationship between the inverse expression of pRb2/p130 and vascular endothelial growth factor (VEGF) and tumor aggressiveness. Together, they may act as a biomarker for hepatocarcinoma (HCC) or liver cancer.
The Corning® 500 cm 2 Square DW Spillguard Cell Culture Dish is offered for culturing large numbers of anchorage dependent cells. Spillguard multilayer film protects against media spills and contamination during handling and transport to the incubator.