Hy-PIPs hybrid phosphoinositide analogs, for use in lipid signaling research and drug discovery, behave like endogenous phosphoinositides and offer improved aqueous solubility.
The Eppendorf epMotion 5070 liquid handling workstation enables rapid and reproducible liquid handling through automated pipetting, dispensing, and dispensing variants. Pipetting sequences and protocols previously carried out manually can now be transferred quickly and easily to the epMotion 5070.
QTL Lightspeed Kinase Activity Assays are a universal mix and measure product that does not require antibodies or radioactive labels. The technology combines sensitivity with speed for high-throughput screening of kinases, based on fluorescence "superquenching" technology.
Bio-Rad Laboratories, Inc. has announced six bead-based phosphoprotein assays for its Bio-Plex suspension array system. The products include: phospho-p70 S6 kinase, phospho-p90RSK, phospho-STAT2 and phospho-TrkA, total Akt, and total p90RSK.
Histone Deacetylases (HDAC) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, a process which is associated with chromatin condensation and transcriptional repression.
CyBi-Lumax flash HT flash luminescence reader, for functional screening of G-protein coupled receptors and calcium channels, features a new 16-channel dispenser that enables flash luminescence reading times of less than 60 seconds for 384-well plates and less than 3 minutes in the 1536-well format.
Cytomat 44 automated storage module is a compact system designed to provide stable microplate storage conditions and to maximize compound integrity.
Millipore 384-well MultiScreen HTS filter plates are offered for high throughput bioassays, including receptor-ligand binding and enzyme assays. Available with glass fiber or phosphocellulose (PH) paper, the filter plates’ automation compatibility increases throughput on a range of robots.
The Biomek FX ADMETox Workstation, for in vitro drug permeability measurements, is a validated system that automates the PAMPA (Parallel Artificial Membrane Permeability Analysis) method for the determination of passive absorption of a drug candidate through an artificial lipid membrane.
ExplorerPLS Automated Microwave Reaction Workstation is offered for speciation studies in analytical chemistry, as well as discovery or optimization of drug candidates in medicinal chemistry. A 24-sample deck with interchangeable racks maximizes throughput.
HiPerFect Transfection Reagent is offered for the transfection of eukaryotic cells with siRNA, and can be used with low siRNA concentrations. Transfection of the lowest effective siRNA concentration minimizes the likelihood of off-target effects.
Trevigen has introduced the E-3 Western assay system. The methodology utilizes free solution pulsed electrophoresis in specially formulated buffers to quickly move charged protein molecules in solution. The process establishes the rapid formation of stable and highly specific immune complexes.
MabSelect Xtra is a recombinant protein A-based chromatography medium that captures antibodies with efficiency and economy. It is engineered to provide high dynamic binding capacity.
Array 900miRNA microarray labeling kits are offered specifically for use with microRNA, siRNA and other small RNA molecules (tRNA, 5S rRNA, nuclease fragments, etc).
The Protein 280 ex lifetime spectrofluorometer measures three fluorescence lifetimes in just a few minutes. Time-Correlated Single-Photon Counting, a time-resolved fluorescence technique, is used to record reproducible lifetime data.