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Pre-Validated Kinase Sequencing Assays

June 22, 2004 9:57 am | Articles | Comments

An expanded SNP discovery service has been launched for pre-validated sequencing assays of kinases, genes implicated in many human diseases.

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Recombinant Proteins

June 22, 2004 9:57 am | Articles | Comments

Proprietary recombinant proteins are ideal for use as positive controls in a variety of applications, including in vitro transcription assays, as EMSA controls in DNA-protein interaction studies, and as protein standards in ELISAs and Westerns.

Direct-Labeled Probe

June 22, 2004 9:57 am | Articles | Comments

New 450 kb probe detects alterations to the HER-2/ neu proto-oncogene (also called ERBB2), and is over-expressed in some breast, ovarian, prostate, and colorectal cancers, playing a possible role in tumor-cell proliferation, tumor invasion, and tumor metastasis.

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Immunology Research Catalog

June 22, 2004 9:57 am | Articles | Comments

Immunology line includes cytokine ELISA kits, cytokine ELISA construction kits, recombinant cytokines, growth factors, monoclonal and polyclonal antibodies, cytokines and CD markers, and matched antibody pairs. Custom immunological services are now available.

Caspases

June 22, 2004 9:57 am | Articles | Comments

Alexis Biochemicals offers over 240 enzymes, antibodies, inhibitors, assay kits, and other products for studying the role of caspases in apoptosis and inflammation.

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Adipogenesis Assay Kit

June 22, 2004 9:57 am | Articles | Comments

The Adipogenesis Assay Kit provides a convenient format for the induction and analysis of adipogenesis in the classic 3T3-L1 model. The most commonly used inducers of adipogenesis — dexamethasone, IBMX, and insulin — are provided in ready-to-use formulations.

HAT Activity Assay Kit

June 22, 2004 9:57 am | Articles | Comments

Histone acetyltransferases (HATs) play a crucial role in a variety of cellular functions such as gene transcription, differentiation, and proliferation. This HAT assay kit utilizes active recombinant HAT protein as a positive control and acetyl-CoA as a cofactor.

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Membrane Protein

June 22, 2004 9:57 am | Articles | Comments

Epidermal Growth Factor receptor (EGFr) 170 kDa membrane protein is expressed in many normal epithelial tissues, particularly in the basal layers of stratified or pseudostratified and squamous epitheliums.

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Bead-Based Assay Kits

June 22, 2004 9:57 am | Articles | Comments

LiquiChip™ bead-based xMAP™ assay kits facilitate research in drug discovery, cell signaling, oncogenesis, apoptosis, and immune disorders. Optimized immobilized substrates enable detection of a wide range of Tyr and Ser/Thr kinase activities without the need for radioactivity.

Human Growth Hormone ELISA

June 22, 2004 9:57 am | Articles | Comments

Bioactive hGH ELISA, for the measurement of biologically active human growth hormone, detects monomeric GH isoforms that possess both receptor binding sites, and thus is capable of receptor dimerization.

HSP27 (Heat Shock Protein) ELISA (3323)

June 22, 2004 9:56 am | Articles | Comments

HSP27 [pS82] phosphoELISA™ is sensitive to 1,000 cells/well, demonstrated with HeLa cell lysates. Additional validated cell lines include THP-1, HT1080, Jurkat and 293 cells.

HDAC8 Activity Assay (3321)

June 22, 2004 9:56 am | Articles | Comments

HDAC8 Colorimetric/Fluorometric Activity Assay/Drug Discovery Kit is HTS-friendly assay and allows real-time monitoring of HDAC activity. This is made possible by HDAC-TRAC™ substrate and buffer, which also enables a choice of either colorimetric or fluorometric detection.

Bayer Adopts Tripos Informatics Technology to Streamline Drug Discovery 06/21/04

June 21, 2004 10:53 am | Articles | Comments

By Catherine Shaffer The preclinical phase of drug development is a large portion of the total expense of research and development, with much of this effort focused on generating new chemical compounds and screening them for activity against disease targets. Bayer Healthcare, Leverkusen, Germany, has adopted a new informatics software system to help manage these millions of compounds.

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Statistical Megastudy Turns Up Genetic Surprise for Pravastatin Patients 6/16/04

June 16, 2004 12:32 pm | Articles | Comments

By Catherine Shaffer A new pharmacogenetic study of cholesterol-lowering statin drugs could lead to better treatment for millions of patients. A collaboration among Harvard Medical School, Brigham and Women's Hospital, both in Boston, and the defunct Variagenics Inc., formerly of Cambridge, Mass., published in the June 16 issue of the Journal of the American Medical Association (JAMA)

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Telltale Heart: Celera Diagnostics Finds Markers of Myocardial Infarction Risk 6/15/04

June 15, 2004 11:27 am | Articles | Comments

By Don Monroe Celera Diagnostics (CD), Alameda, Calif., disclosed two more genetic markers that it says are associated with heart-attack risk in caucasians. Although the work is still in an early stage, this type of marker "could be useful in identifying people who should be on statins, or other cholesterol-lowering agents, who otherwise might not be candidates," says Thomas White, chief scientific officer at the company.

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