by Catherine Shaffer Two groups of researchers, working independently and using comparative genomic methods, identified a host of genes involved in the formation of cilia and flagella. Defects in these microtubule-based structures, which humans share with all animals and many unicellular organisms such as the algae Chlamydomonas, are blamed for various disorders, such as poor sperm motility, respiratory disorders, kidney disease, and blindness. The genes identified may offer novel drug targets for these disorders.
by Mark Terry Researchers at the Fox Chase Cancer Center, Philadelphia, linked Alzheimer's disease (AD) to a protein that helps cancer cells resist anti-tumor drugs. The protein, ABCA2, is associated with resistance to the cancer drug estramustine. It has also been linked to myelination and nervous system development. Involved in cellular transport, ABCA2 has also been associated with cholesterol loading. A recent report suggests there may be a connection between the transport molecule and the mechanisms behind AD.
by Jill Taylor With help from a grant from the National Institute of General Medical Sciences, the MetaCyc database, a metabolic pathway database that allows researchers to visualize metabolic pathways from more than 230 organisms, will soon be expanding both its content and the supporting software tool kit to provide additional querying capabilities, and a richer set of visualizations.
by Elizabeth Tolchin Researchers identified an enzyme that plays a key role in the recognition of misfolded proteins. The finding, say the researchers, may offer a potential target for several degenerative diseases, including cystic fibrosis, diabetes, and Alzheimer's disease.
by Elizabeth Tolchin In a recent study Hoffmann-La Roche used single nucleotide polymorphism (SNP) discovery and genotyping technologies provided by ParAllele BioScience to identify genetic risk factors for type 2 diabetes.
by Mark Terry Researchers identified a relationship between the inverse expression of pRb2/p130 and vascular endothelial growth factor (VEGF) and tumor aggressiveness. Together, they may act as a biomarker for hepatocarcinoma (HCC) or liver cancer.
The Corning® 500 cm 2 Square DW Spillguard Cell Culture Dish is offered for culturing large numbers of anchorage dependent cells. Spillguard multilayer film protects against media spills and contamination during handling and transport to the incubator.
FiberCell® Systems Duet hollow fiber modules are offered for cell culture scale-up for antibody and recombinant protein production.
by Elizabeth Tolchin With so much genetic expression data being produced by microarrays in the study of cancer, knowing the extent to which these studies agree can provide valuable insight. That is just what researchers from Johns Hopkins University, Baltimore, set out to find.
Rapid Fractionation Of Complex Protein Extracts With Centrifugal MembraneAdsorber Units Improves Detection Of Proteins In 2d PageMay 19, 2004 10:51 am | Articles | Comments
Two-dimensional gel electrophoresis followed by mass spectrometry for protein identification is a reliable and reproducible means of sample analysis. A key element in this process is reducing sample complexity, as samples often consist of tens of thousands of proteins in a magnitude of different concentrations.
by Elizabeth Tolchin In a notice issued this week, the US Food and Drug Administration (FDA) announced a new guidance to encourage the development of fixed dose combinations (FDC) and copackaged products for the treatment of HIV infection and AIDS.
The fully automated TekBench liquid handling system for cell-based assays includes ELISA, ADME/TOX, Plasmid Prep, and RNA/DNA Isolation.
The high-capacity, variable-speed Rotating Mixer mixes 50 0.5-mL and 48 1.5-mL centrifuge tubes with snap-on or screw-down caps in an end-over-end motion at speeds varying from 4 to 40 rpm.
The 323 pump provides high-precision pumping in pharmaceutical and biotechnological processes. It is ideal for lab and benchtop applications such as metering or dosing of pharmaceutical products, live cell cultures, nutrients, or bioreactor constituents.
DRYFAST ULTRA® chemical duty diaphragm pumps (models 2021 and 2031) are ideal for tight spaces and budgets. PTFE (fluorinated plastics) is featured on all wetted surfaces to handle acids, bases, and other aggressive vapors. High-flow (22 to 32 Lpm) and deep vacuum (29.