Signaling research line includes antibodies for the Akt pathway, cell cycle and Checkpoint control, cytokines, DNA damage, the NfkB pathway and for ubiquitin.
Expanded line of iso-IHC Core kits come with the components required for performing iso-IHC, except the substrate-chromogen system, which the user can select from the Core Kit Accessories. Users have the freedom to work with the chromogenic system of choice.
Caspase-Glo 8 and Caspase-Glo 9 assays offer sensitive apoptosis detection. The homogeneous assay protocol for Caspase 8 & 9 provides results in 20 minutes.
Purified monoclonal antibody raised against human Interleukin-19 is available from R&D Systems. IL-19 is a novel member of the multifunctional IL-10 family. It is secreted as a monomer that contains a unique bundle of seven amphipathic helices.
Lightspeed kinase assays, quenching fluorescence-based assays for drug discovery, are offered for PKCa (diabetes and leukemia), Akt-1 (cancer), Src (cancer) and p38a (leukemia and lymphoma).
Anti-mPDCA-1 antibodies provide specific detection and isolation of murine plasmacytoid dendritic cells (mPDCs).
Human IL-2 and Bovine TNF alpha Screening Sets are offered for development of 5 colorimetric ELISA plates each.
Cell Cycle Assay (Guava Technologies, Inc.) incorporates staining reagents pre-combined in a single optimized format, eliminating reagent preparation following cell fixation. Protocols are offered for use with either individual tubes or 96-well microplates, minimizing assay development time.
In vitro-derived, recombinant antibody is targeted against human Cyclophilin A, which is indicated to play an important role in the mechanism of protein folding. Recently a number of diseases have been linked to protein folding problems.
Charles River Proteomic Services Inc. (Worcester, MA) and GenWay Biotech Inc. (San Diego, CA) have collaborated to produce avian IgY polyclonal antibodies that function as a fractionation step prior to protein separation.
Parkinson's Disease (PD) is a movement disorder resulting from degeneration of dopaminergic neurons in the substantia nigra pars compacta. The gene encoding human parkin has been linked to an autosomal recessive form of PD.
Ghrelin is a 28 amino acid peptide synthesized in the stomach that acts to stimulate food intake and help maintain energy homeostasis. Post-translational modification by n-octanoylation at serine 3 is essential for biological activity.
BD Falcon 96-Multiwell Insert System is a cell culture insert platform suitable for both manual and robotic screening of compounds in cell-based assays.
CytoScan-LDH measures cytosolic enzyme lactate dehydrogenase (LDH) release as cells die. Released LDH is measured with a color producing diaphorase linked tetrazolium salt reaction. The amount of color produced is proportional to the number of cell deaths.
Assay Designs has introduced an immunoassay for the quantitative determination of human Smac/DIABLO in cell lysates. The colorimetric, 96 well-plate format measures Smac/DIABLO concentration with a range of 31.25 to 1000 pg/ml. The three-hour assay is non-radioactive, stable, and sensitive to 7.