by Elizabeth Tolchin Patients with a rare inherited form of Parkinson's disease (PD) have an excess of the alpha-synuclein (aSyn) producing gene, creating a buildup of protein inside brain cells, resulting in a condition that resembles symptoms of PD. New research uses a yeast model to better understand how and when the gene's production of alpha-synuclein becomes harmful to surrounding cells.
by Elizabeth Tolchin Lexicon Genetics Incorporated obtained a patent this weak entitled "High Efficiency Gene Targeting in Mouse Embryonic Stem Cells" that covers methods of producing genetically engineered knockout mice by gene targeting.
by Elizabeth Tolchin A protein called ARF, known to play a role in tumor suppression, may also play a role in cell growth.
by Elizabeth Tolchin Mistakes happen, even with RNA polymerase (RNAP), the enzyme that copies genes from DNA into strands of RNA.
by Elizabeth Tolchin In a determination by the US Food and Drug Administration (FDA), Roche Diagnostics will not yet be able to sell the AmpliChip CYP450, a microarray developed
Custom Microarray Services from TeleChem International, Inc. are performed in Class 100 cleanrooms using advanced surfaces and coupling chemistries. Flex-Chips service allows customers to send confidential samples for arraying.
ProSeq provides proprietary, high efficiency chemistry for protein sequencing on PVDF immobilized samples. Unique methodology identifies internal sequence of N-blocked proteins.
Taconic Biotechnology supplies monoclonal antibodies used in research, diagnostic and therapeutic applications from a cGMP production facility.
Perry Scientific specializes in preclinical animal studies and offers a complete range of services, animal models and surgical techniques. Services include most types of "in vivo" studies, including oncology and toxicology models, as well as large animal and device studies.
MacConnell Research Corporation provides custom sequencing. Universal primers such as T7, T3, SP6, M13 forward and reverse are provided. Custom primers must be provided at a concentration of 1 pmol/μl. Between 750-1000 bases can typically be read per run, depending on DNA quality.
Kendrick Labs specializes in protein electrophoresis as a service for academia, federal institutions and industry. The company specializes in 2-D gel electrophoresis, a method that generally has a turnaround time of about a week.
GenUs BioSystems, Inc. bioarray service laboratory provides a full range of services related to bioarray experimentation, including sample preparation, sample quality analyses, processing of customer-provided RNA and DNA on bioarrays, and downstream data analysis.
Located in Woodridge, Ill., deCODE genetics' pharmaceuticals group offers chemistry-based drug
Charles River Laboratories has expanded its biopharmaceutical services business site. Now 34,000 square feet, the unit offers GMP-compliant biological drug development services.
ATG Laboratories offers cloning, expression, and purification services and for consulting in specialty areas. Cloning services include subcloning, PCR cloning, RT-PCR cloning, site-directed mutagenesis and DNA sequence analysis.