News and applications for life science research professionals
Targeted Drug and Gene Delivery with Microbubbles 1/28/04
January 28, 2004 11:33 am | Articles | Commentsby Elizabeth Tolchin A technique that uses ultrasound energy to create microbubbles inside specially treated liposomes and then directs the liposomes to specific targets may offer a new method for targeted gene therapy and drug delivery.
Protein Modification Kills Cancer Cells 1/27/04
January 28, 2004 9:58 am | Articles | Commentsby Elizabeth Tolchin A recently discovered protein plays a role in preventing cell death when DNA damage occurs. Cells with DNA damage are able to remain alive, furthering the development of cancer.
Companies Collaborate on Canadian Haplotype Map 1/26/04
January 26, 2004 11:59 am | Articles | Commentsby Elizabeth Tolchin Two companies plan to work together to create a Quebec Linkage Disequilibrium Map (QLDM) consisting of approximately 40,000 single-nucleotide polymorphisms (SNPs).
Microarrays Support Reporter Assays for Antibacterial Drug Discovery 1/23/04
January 23, 2004 12:44 pm | Articles | Commentsby Elizabeth Tolchin Researchers demonstrated a new microarray-supported approach for developing pathway-specific assays for high-throughput screening of compound libraries.
Finding the Return on Microarrays 1/22/04
January 22, 2004 11:52 am | Articles | Commentsby Elizabeth Tolchin Illumina Inc. recently announced two new Sentrix BeadChips for whole-genome expression profiling of multiple samples on a single chip. The new six-sample whole-genome BeadChip is to compete with microarray products that analyze one genome on a chip.
HIP Chemical Genetic Screens Uncover Drug Targets 1/21/04
January 21, 2004 12:45 pm | Articles | Commentsby Elizabeth Tolchin Experiments with chemical genetic screens for finding new drug targets led to a method that uses a yeast culture to identify the gene products that functionally interact with small molecules and inhibit cell proliferation.
Protein Crystallization With Minimal Frustration 1/20/04
January 20, 2004 12:27 pm | Articles | Commentsby Elizabeth Tolchin A new technique called enhanced amide hydrogen/deuterium-exchange mass spectrometry, or DXMS, promises to take some of the frustration out of protein crystallization.
Powdered Growth Media
January 20, 2004 3:34 am | Articles | CommentsTB DRY™ is a single powder formulation of the classic Terrific Broth. It is primarily used to grow E. coli cultures harboring low copy plasmids. Specifically designed to give high yields of low copy plasmids and extremely high yields of high copy plasmids, the media is pH stabilized with Tris.
Bench Top Roller Culture Apparatus
January 20, 2004 3:34 am | Articles | CommentsThe Wheaton Bench Top Roller Culture basic unit can accommodate two vessels of varying sizes from 108 to 121 mm diameter and up to 290 mm length. If required, the basic unit can be expanded to accommodate four or six vessels by the addition of one or two, two-place deck kits.
Cell Separation, Harvesting
January 20, 2004 3:34 am | Articles | CommentsThe CARR® ViaFuge® V12 separation system provides fast, gentle, medium-to-large scale supernatant clarification and cell harvesting. A wide variety of mammalian and insect cells are rapidly separated with little to no damage, up to production scale quantities.
Dendritic Cell Counting Kit
January 20, 2004 3:34 am | Articles | CommentsBlood Dendritic Cell Enumeration Kit, based on recently described dendritic cell-specific surface antigens BDCA-2, BDCA-3 and CD1c (BDCA-1) (Dzionek et al., J. Immunol.
On-Line Media Reference
January 20, 2004 3:34 am | Articles | CommentsSigma-Aldrich has launched a new Web tool, the Media Expert™ at www.sigma-aldrich.com/me, to assist customers with cell culture media component and formulation issues.
Sterilize-In-Place Fermentor
January 20, 2004 3:34 am | Articles | CommentsBioFlo® 410 benchtop microbial fermentors are available in 7, 14 and 20-liter volumes and can be sterilized-in-place, eliminating the need to transport heavily-loaded vessels to and from the autoclave.
Disposable Flask/Bioreactor
January 20, 2004 3:34 am | Articles | CommentsCELLine adhere, a disposable flask-bioreactor is optimized for protein expression from adherent cells, incorporates a woven polyethylene teraphthalate (PET) matrix in the cell compartment to provides an ideal surface for attachment of anchorage dependent cells such as HEK, BHK and CHO.
Antibiotic Protects Primary Cells
January 20, 2004 3:34 am | Articles | CommentsPrimocin™ is a new combination of antibiotics designed to protect primary cells against all types of microbial contaminants, including mycoplasma, bacteria and fungi. The antibiotic acts on targets found only in microorganisms so it is nontoxic to primary cells.
